Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy.
The development of effective and broad-spectrum antiviral therapies remains an unmet need.Current virus-targeted antiviral strategies are often limited by narrow spectrum of activity and the rapid emergence of resistance.As a result, there is increasing interest in alternative approaches that target host cell factors critical for viral replication.